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Nicotinamide ribose (NR), a derivative of vitamin B3, is the precursor of the noga factor nicotinamide adenine dinucleotide. NR supplementation increases NAD+, which then activates several enzymes that are important for health. NR can increase NAD+ regardless of NAMPT activity, which helps mitigate the aging effects of poor circadian rhythm entrainment. It is promoted as an anti-aging supplement because it boosts your body’s levels of NAD+, which acts as fuel for many key biological processes.