The mucosal surfaces of the gut and airways have important barrier functions and regulate the induction of immunological tolerance. One of the factors determining these functions is secretory immunoglobulin (SIgA and SIgM).
Secretory immunoglobulin deficiency, i.e. lack of secretory immunoglobulins at mucosal sites seems to occur frequently in the general population. It has been correlated to diseases such as:
- recurrent infections
- allergic diseases
- food intolerance
- autoimmune diseases
Up to now, treatment of such diseases focuses on the symptoms and not the potential underlying immunodeficiency. A replacement therapy with polyclonal secretory immunoglobulin may help to lower the incidence of diseases.
We report on promising data on the prophylactic use of a secretory immunoglobulin preparation from bovine whey in an infectious disease animal model.
Who Should Attend and why:
The presentation will give insight into a long neglected - but frequently occuring - immunodeficiency and its correlation with diseases such as allergies, recurrent infections and the development of food intolerance. It will also provide data and thoughts about replacement therapy with secretory immunoglobulin preparations from milk. Angothera is seeking collaboration partners for the further development of functional food and nutraceutical products for treatment of mucosal immunoglobulin deficiency.