RESERVE PAPER: How to efficiently deliver probiotic to intestine

07 May 2014
14:22 - 14:45

The delivery of acid sensitive actives in the gastrointestinal tract (GIT) requires specific formulation technology that can act as protection against harsh physiological conditions. Recently, vegetarian capsules based on hypromellose have become commercially available (for example, Vcaps¨, Vcaps¨ Plus and DRcapsª). Among them, DRcapsª shows a dissolution profile that is resistant at low pH (1.2).

The objective of this paper is to demonstrate the efficacy of DRcapsª in protecting and delivering pure probiotic and enzymatic activities under gastrointestinal relevant conditions such as fasted and fed status, using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME¨) technology platform. To assess this in-vitro models, an in-vivo scintigraphy study was performed confirmed the delivery of ingredients into the intestinal environment.

Furthermore, shelf life stability of probiotics was confirmed in vegetal capsules up to 2 years in blister and bottles.

Finally, customers panels confirmed that DRcapsª has a superior organoleptic performance, assessed by the reduction or absence of an after taste and higher digestive confort.

Who Should Attend and why:

Delegates operating in the environment of food supplement will learn about a new innovative capsule dosage form offering a solution for acid senstive ingredients such as probiotics. R&D oriented delegates will get acces to the scientific in vivo data demonstrating functionnlity of the capsule. For Business developement or marketing attendees, the presentation will give more inight in new opportunities for launching new products or line extension that are offering an enhanced consumer compliance. Formulators delegates will get some inisghts on how some manufacturing steps can be eliminated, dirving cost reduction and sustainability.

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